Exosomal Beauty Has Arrived: Small Yet Powerful

**Intro: Exoceutical’s skin care, featuring its eXo3 exosome technology, delivers “proteins, growth factors, nucleic acids and MiRNAs to promote regeneration and healing,” per the brand.

Exoceuticals made a splash at the Cosmoprof North America trade show in Las Vegas from July 23-25, 2024, signaling a new era of exosome-driven regenerative beauty that enhances skin longevity.

What Are Exosomes?
Exosomes are tiny particles ranging from approximately 30-200 nm in size, containing genetic material, proteins, and fats. In the context of skin health, they can signal other cells to initiate repair and rejuvenation processes.

This leads to improved skin health, transitioning from superficial repair methods to a genuine regenerative approach in anti-aging treatments. Notably, some professional beauty procedures utilize clients’ own human exosomes, while consumer products typically use plant-derived alternatives.

A 2024 study published in the journal Cell Communication and Signaling stated, “Anti-aging features of exosomes have been implicated in various in vitro and pre-clinical studies. Stem cell-derived exosomes can restore skin physiological function and regenerate or rejuvenate damaged skin tissue through various mechanisms such as decreased expression of matrix metalloproteinase (MMP), increased collagen and elastin production, and modulation of intracellular signaling pathways as well as intercellular communication.”

Exoceuticals’ Exosome Play
Exoceuticals features its eXo3 exosome technology, which delivers “proteins, growth factors, nucleic acids and MiRNAs to promote regeneration and healing,” according to the brand. This technology enhances cellular communication, potentially slowing the aging process while improving skin health and rejuvenation.

The benefits include healing and regeneration after sun exposure and environmental damage. Additionally, because exosomes enhance cellular communication—which tends to decline with age—they can reduce the appearance of wrinkles, crow’s feet, and dark spots, while increasing elasticity.

Co-founded by Robin L. Smith, MD, MBA, and Nicole Martin, MD (of Real Housewives of Miami fame), Exoceuticals offers a range of products, including the Exo H-Serum Hyaluronic Acid Treatment, Exo Face Perfection Moisturizer, Exo Sun After-Sun Treatment, Exo Plus Anti-Aging Cream, Exo C-Serum Vitamin C Treatment, Exo Body Advanced Body Lotion, and Exo Men Hydrating Moisturizer.

These products reportedly reduce the appearance of crow’s feet after just seven days while also enhancing skin firmness. Exosomal Beauty Has Arrived: Small Yet Powerful.

Exoceuticals is not alone in this innovation; exosomes have emerged as a significant trend in beauty technologies. Vytrus Biotech has developed intact plant exosomes for skin and hair care, while DSM-Firmenich is collaborating with ExoLab Italia to introduce plant-derived exosome technology to the global skincare market.

Active Concepts has also launched its BioAuthentic Exosomes line, utilizing green chemistry principles. Additionally, Korea’s J2KBio Co., Ltd. introduced Lactosome 55, a skin care active derived from exosomes obtained from Lactobacillus brevis J2K-55, originally isolated from water radish kimchi. This biofermented ingredient is said to enhance skin barrier function, aid in wound healing, and promote skin brightening.

Among the brands harnessing the power of exosomes is Beekman 1802, which features the Milk RX Advanced Better Aging Cream with goat milk protein exosomes that penetrate deeper into skin layers to fortify the skin barrier and enhance skin longevity. Exosomal Beauty Has Arrived: Small Yet Powerful.

Courtesy of Exoceuticals

The cream includes Renexosome, Beekman 1802’s polypeptide complex that combines goat milk exosomes with a polypeptide. This complex is reportedly four times more effective than retinol in promoting collagen production while being safe for sensitive skin, avoiding the irritation often associated with traditional retinol. The Renexosome’s goat milk exosomes are rich in keratin and immunoglobulins, with an average size of 102.8 to 109.3 nanometers and a concentration of around 116 billion particles per milliliter.

The complex also features LipoTrue’s Reneseed regenerative polypeptide, derived from vertically farmed N. benthamiana, which mimics retinol effects by accelerating collagen production by 31% without causing irritation or peeling. The outcome is a visibly firmer skin barrier, illustrating that Exosomal Beauty Has Arrived: Small Yet Powerful.